Expression of Asialoglycoprotein Receptor 1 in Human Hepatocellular Carcinoma

Upregulation of Endothelin-1/Endothelin A Receptor Expression Correlates with Heparanase Expression in Ovarian Carcinoma

Background: Heparanase and endothelin-1/endothelin A receptor (ET-1/ETAR) expressions increase in cancer. This condition enhances tumor progression and correlates with poor survival. Limited data are documented regarding the role of heparanase and ET-1/ETAR in epithelial ovarian cancer (EOC). We sought to characterize the correlation between heparanase and ET-1/ETAR in EOC.Methods: Thirty patie...

Expression and clinical significance of angiotensin II type 1 receptor in human hepatocellular carcinoma

This study aimed to investigate the expression of angiotensin II type 1 receptor (AT-1R) mRNA and the AT-1R protein in human primary hepatocellular carcinoma (PHC), and to attempt to elucidate their association with pathological and clinical characteristics. Fresh tumor and normal liver tissues were obtained from 44 patients with PHC following hepatectomies. AT-1R mRNA levels were quantitativel...

Hepatocellular Carcinoma in Sheep

Detection of Circulating Tumor Cells in Hepatocellular Carcinoma Using Antibodies against Asialoglycoprotein Receptor, Carbamoyl Phosphate Synthetase 1 and Pan-Cytokeratin

BACKGROUND Asialoglycoprotein receptor (ASGPR)-ligand-based separation combined with identification with Hep Par 1 or pan-cytokeratin (P-CK) antibody have been demonstrated to detect circulating tumor cells (CTCs) in hepatocellular carcinoma (HCC). The aim of this study was to develop an improved enrichment and identification system that allows the detection of all types of HCC CTCs. METHODS ...

Enhanced RBM8A expression in human hepatocellular carcinoma

Objective: To investigate the expression level of RBM8A and its significance in HCC. Methods: RT-PCR method, immunohistochemistry and Western blot assay were performed to detect RBM8A expression in 105 cases of HCC tissues, adjacent tissues and 67 cases of normal liver tissues; The relationship between RBM8A expression and clinicopathological features of HCC was analyzed. Results: RT-PCR showed...